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The story

Since its creation in 1987 by Christian Diehl, a pharmacist based in Bourg-en-Bresse, France, Isispharma Laboratory has focused its research on the natural balance – homeostasis – and the imbalances of the skin to develop innovative and effective solutions to help each patient suffering from skin problems regain healthy skin.

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Pioneering in the treatment of specific skin disorders such as hyperpigmentation, rosacea, and vitiligo, Isispharma quickly became renowned among dermatologists and patients for the efficacy of its solutions.

Since it was acquired in 2002 by the DEWAVRIN Group, a family-owned business specialized in the health and beauty industry, the laboratory has accelerated its international expansion while continuing to develop innovative and effective solutions.

Today, Isispharma’s skincare products are recommended by over 14,000 dermatologists in 80 countries.

  • 1987

    Creation of the Isispharma laboratory by a pharmacist in Bourg-en-Bresse, France.
  • 1987 – 2002

    Development of Unitone, Ruboril, and Vitiskin formulas and distribution in several countries for export.
  • 2002

    Acquisition of the laboratory by the DEWAVRIN Group, a 100% family-owned company specializing in the health and beauty industry.
  • 2015

    Isispharma is the first dermocosmetic brand to successfully formulate 15% azelaic acid for the launch of its star product Metroruboril A.Z, the tailored care that precisely targets persistent redness.
  • 2016

    Start of collaboration with independent research institutes (CNRS).
  • 2018

    Renovation of the Neotone range that precisely targets the 5 major causes of dark spots for visible and long-lasting depigmentation.

    Texture innovation! Launch of the first and only 100% emollient dermocosmetic spray: Xerolan for severe and localized xerosis.
  • 2019

    Publication of clinical study demonstrating comparable efficacy between Neotone and the reference molecule ; JEADV.
  • 2020

    Clinical Study on Metroruboril AZ vs Metronidazole showing better efficacy.
  • 2022

    Launch of Teen Derm AZ, the tailored care that precisely targets severe imperfections, and one of the pioneer care at 15% acid azelaic for acne-prone skin.
  • 2023

    Isispharma International Dermatology Summit: The first edition of a flagship event that brought together numerous dermatologists specializing in pigmentation from around the world.
  • 2024

    Publication in Dermatology and Therapy Journal of the Teen Derm A.Z vs. Antibiotics clinical study.
  • 2025

    Launch of the 1st dermatological Sun Serum in the world of dermocosmetics..